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CAS

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606968-05-2

Methylene-Bis Paroxetine Dihydrochloride, also known as Paroxetine EP Impurity F, is a chemical compound derived from Paroxetine, a selective serotonin reuptake inhibitor (SSRI) commonly used as an antidepressant. It is characterized by its ability to act as a chiral reference substance in analytical methods.

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  • 606968-05-2 Structure

  • Basic information

    1. Product Name: Methylene-Bis Paroxetine Dihydrochloride
    2. Synonyms: Methylene-Bis Paroxetine Dihydrochloride;3,3'-[Methylenebis(1,3-benzodioxole-6,5-diyloxyMethylene)]bis [4-(4-fluorophenyl)piperidine DiHydrochloride;Bis(3,4-Methylenedioxy-6-[(3S,4R)-4-(4-fluorophenyl)piperidine-3-ylMethoxy]Methane DiHydrochloride;Paroxetine EP IMpurity F;Bis {3,4-methylenedioxy-6-[(3S,4R)-4-(4-fluorophenyl) piperidine-3 -ylmethoxy]phenyl} methane
    3. CAS NO:606968-05-2
    4. Molecular Formula: C39H40F2N2O6
    5. Molecular Weight: 670.7415064
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 606968-05-2.mol

  • Chemical Properties

    1. Melting Point: 196-199?C
    2. Boiling Point: 749.4±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.258±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Slightly)
    9. PKA: 9.99±0.10(Predicted)
    10. CAS DataBase Reference: Methylene-Bis Paroxetine Dihydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: Methylene-Bis Paroxetine Dihydrochloride(606968-05-2)
    12. EPA Substance Registry System: Methylene-Bis Paroxetine Dihydrochloride(606968-05-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 606968-05-2(Hazardous Substances Data)

606968-05-2 Usage

Uses

Used in Pharmaceutical Industry:
Methylene-Bis Paroxetine Dihydrochloride is used as a chiral reference substance for the chiral purity determination of Paroxetine drug substance. This application is crucial in ensuring the quality, safety, and efficacy of Paroxetine-based medications, as it helps to identify and quantify the presence of impurities that may affect the drug's performance.
Used in Chiral HPLC Method:
Methylene-Bis Paroxetine Dihydrochloride is utilized in the chiral high-performance liquid chromatography (HPLC) method for the analysis and determination of the enantiomeric purity of Paroxetine. This method is essential in the pharmaceutical industry to guarantee the consistency and reliability of Paroxetine medications, as well as to comply with regulatory requirements for drug quality and purity.

Check Digit Verification of cas no

The CAS Registry Mumber 606968-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,6,9,6 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 606968-05:
(8*6)+(7*0)+(6*6)+(5*9)+(4*6)+(3*8)+(2*0)+(1*5)=182
182 % 10 = 2
So 606968-05-2 is a valid CAS Registry Number.

606968-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Methylene-Bis Paroxetine Dihydrochloride

1.2 Other means of identification

Product number -
Other names (4R)-4-(4-fluorophenyl)-3-[[6-[[6-[[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy]-1,3-benzodioxol-5-yl]methyl]-1,3-benzodioxol-5-yl]oxymethyl]piperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:606968-05-2 SDS

606968-05-2Downstream Products

606968-05-2Relevant articles and documents

Method for preparing paroxetine impurity

-

Paragraph 0050; 0051, (2017/08/29)

The invention provides a method for preparing paroxetine impurity. The method comprises the following steps: putting paroxetine or salt thereof into a reaction solvent, reacting with aldehyde solution in an acidic system and then separating, thereby acquiring a target product 4,4'-methylene paroxetine biopolymer. The method for preparing paroxetine impurity provided by the invention has the advantages of simple operation, high product yield, high purity and low cost.

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