60721-38-2Relevant academic research and scientific papers
N-(1-ARYL-2,2,2-TRIHALOGENOETHYL)CARBOXAMIDES
Bal'on, Ya. G.,Smirnov, V. A.
, p. 2051 - 2054 (2007/10/02)
The readily obtained products from the condensation of trihalogenoacetaldehydes with carboxamides react with benzene and its homologs in the presence of concentrated sulfuric acid with the formation of N-(1-aryl-2,2,2-trihalogenoethyl)carboxamides.The latter were used for the production of 1-aryl-2,2,2-trihalogenoethylamines and 1-acylimino-1-aryl-2,2,2-trihalogenoethanes.
INTRA VS INTERMOLECULAR AMIDOALKILATION OF AROMATICS
Ishai, D. Ben,Sataty, I.,Peled, N.,Goldshare, R.
, p. 439 - 450 (2007/10/02)
Three tipes of intramolecular amidoalkylation reactions of aromatics, two endotrigonal and one exotrigonal (I, II, III), leading to indolone, N-acylisoquinolines, isoquinolone and benzazepinone derivatives were studied.In the presence of external aromatic nucleophiles competing intermolecular amidoalkylations were observed (1->2, 13->14).The mechanism and the synthetic limitations of the three types of cyclization is discussed.
INTER VS INTRAMOLECULAR AMIDOALKYLATIONS OF AROMATICS - A NEW SYNTHESIS OF OXINDOLES, ISOQUINOLONES AND BENZAZEPINONES
Ben-Ishai, D.,Peled, N.,Sataty, I
, p. 569 - 572 (2007/10/02)
A new synthesis of oxindoles (8) isoquinolones (5) and benzazepinones (10) by the intramolecular amidoalkylation of aromatic amides of bismethoxycarbonylaminoacetic acid (4, 7, 9) is described.
