60722-63-6Relevant academic research and scientific papers
Solid phase synthesis of diamino-substituted pyrimidines
Barillari, Caterina,Barlocco, Daniela,Raveglia, Luca F.
, p. 4737 - 4741 (2007/10/03)
2,4- and 4,6-Diamino-substituted pyrimidines are known for their biological activity in many therapeutic areas. A novel solid-phase synthesis of this class of compounds by nucleophilic aromatic substitution has been set up and the reactivity of differently substituted solid-supported pyrimidines with properly selected amines has been studied. Using this methodology a small library of diamino-substituted pyrimidines has been prepared. Wiley-VCH Verlag GmbH, 2001.
Solid-phase synthesis of 2,4,6-triaminopyrimidines
Guillier, Fabrice,Roussel, Patrick,Moser, Heinz,Kane, Peter,Bradley, Mark
, p. 3450 - 3458 (2007/10/03)
Substituted pyrimidines are an important class of kinase inhibitors. We therefore developed a synthetic route suitable for the solid-phase synthesis of 2,4,6-triaminopyrimidines through displacement reactions on deactivated pyrimidines. Functionalising th
