60722-67-0Relevant academic research and scientific papers
Unifying the Aminohexopyranose- and Peptidyl-Nucleoside Antibiotics: Implications for Antibiotic Design
Barrows, Louis R.,Eiler, Daniel,Kanna Reddy, Hariprasada Reddy,Koch, Michael,Looper, Ryan E.,Sebahar, Paul R.,Serrano, Catherine M.,Testa, Charles A.,Tresco, Ben I. C.,VanderLinden, Ryan T.
supporting information, p. 11330 - 11333 (2020/05/18)
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound. Amicetin's binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously determined by crystallography and
ANTIMICROBIAL COMPOUNDS
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Page/Page column 00182; 00183, (2019/02/02)
Disclosed are compounds of formula I: or pharmaceutically acceptable salts thereof. Compounds of formula I are anti-microbials that inhibit, for instance, Mycobacterium tuberculosis (Mtb) H37Ra. Compounds of formula I also have anti-tubercular activity, e
Studies on the synthesis of the derivatives of 5-(dihydroxyboryl)-cytosines and -isocytosines
Wojtowicz-Rajchel, Hanna,Suchowiak, Marek,Fiedorow, Piotr,Golankiewicz, Krzysztof
, p. 841 - 845 (2007/10/03)
Boron derivatives of isocytosine, containing a dihydroxyboryl group in the 5-position, have been prepared for the first time. Reaction of appropriate pyrimidines with n-butyllithium and subsequent boronation at -100°C with triethylborate, followed by catalytic hydrogenation, gave hydrolytically stable N,N-dimethyl-5-(dihydroxyboryl)isocytosine 8a and N-methyl-5-(dihydroxyboryl)isocytosine 8b. Theoretical calculations suggest that the corresponding boron derivatives of cytosine cannot be obtained as thermodynamically stable compounds.
