60725-23-7Relevant articles and documents
Synthesis of novel 2-substituted thiadiazole derivatives
Xue, Shouqing,Ma, Yuanzhong,Li, Weinan
, p. 383 - 387 (2018/06/06)
Seven mild, efficient and novel inhibitors were obtained in good to excellent yield by addition of Thiadiazole derivatives with an acidsmolecular sieve system at moderate temperature (50C). The structures of the prepared compounds are characterized by IR and1HNMR Spectroscopy, and the catalyst can be recovered by filtration and reused several times. The resulted showed that the process was then applied to [1, 3, 4] thiadiazde derivatives using 0.75 g of Catalyst for acids and performing the reactions at 50 °C for 1 hour with sulfuric acid as solvent (15mL, 70%). We have shown for the first time that a heterogeneous catalyst, namely commercially available AlPO45 and SBA15 molecular sieve, can be successfully and efficiently utilized for the highly selective synthesis of 3. Moreover, the use of sulfuric acid as solvent, the high atom economy, and the possibility of recycling the catalyst for several runs, make this approach practical and environmentally acceptable.
