607352-97-6

Upstream product

• 182495-98-3 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyluridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 607352-96-5 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-2-ethoxy-5-methyl-1H-pyrimidin-4-one 
• 607352-94-3 Acetic acid (2R,3R,4R,5R)-2-methanesulfonyloxymethyl-4-(2-methoxy-ethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 844504-15-0 2'-O-(2-methoxy)ethyl-3'-O-acetylthymidine 
• 607352-95-4 2-Ethoxy-1-[(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-4-one 
• 163759-50-0 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 

Downstream Products

• 607353-04-8 Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 

Relevant academic research and scientific papers

Compounds and oligomeric compounds comprising novel nucleobases

The present invention relates to nucleoside compositions comprising novel nucleobases and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity properties compared to oligomeric compounds without the modification. The oligomeric compounds are useful, for example, for investigative and therapeutic purposes.

2'-modified-2-thiothymidine oligonucleotides.

[reaction: see text] Oligonucleotides with novel modifications, 2'-O-[2-(methoxy)ethyl]-2-thiothymidine and 2'-deoxy-2'-fluoro-2-thiothymidine, have been synthesized. These modified oligonucleotides exhibited very high thermal stability when hybridized wi