607394-06-9Relevant academic research and scientific papers
The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: Non-taxane derived mimics of taxol?
Howarth, Joshua,Kenny, Padraic,McDonnell, Susan,O'Connor, Aine
, p. 2693 - 2697 (2003)
In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.
