607691-24-7Relevant articles and documents
Enantioselective synthesis of the carbacephem antibiotic loracarbef via Mitsunobu and Dieckmann cyclization from an unnatural amino acid
Misner, Jerry W.,Fisher, Jack W.,Gardner, John P.,Pedersen, Steve W.,Trinkle, Kristina L.,Jackson, Billy G.,Zhang, Tony Y.
, p. 5991 - 5993 (2007/10/03)
The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which was derived from enzyme-catalyzed condensation of glycine and 4-pentenaldehyde. The bicyclic framework of this compound was established through sequential Mitsunobu reaction and aldol condensations.