60770-68-5

Usage

Uses

Used in Organic Synthesis:
5-Iodo-2-methylbenzofuran is utilized as a reagent in organic synthesis for the creation of complex chemical structures. Its unique chemical properties allow it to serve as a building block, facilitating the synthesis of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-Iodo-2-methylbenzofuran is of interest due to its potential applications in the development of new pharmaceuticals. Its biological and pharmacological activities make it a valuable compound for exploring novel therapeutic agents and drug candidates.
Used in Research and Development:
5-Iodo-2-methylbenzofuran is employed in research and development for its potential to contribute to the advancement of scientific knowledge and the discovery of new applications. Its diverse properties and potential uses make it a valuable tool for researchers in various industries.
Used in Chemical Industries:
5-Iodo-2-methylbenzofuran is applied in chemical industries as a versatile compound with a range of potential applications. Its solubility in organic solvents and unique chemical properties make it suitable for use in the production of various chemical products and materials.
Used in Pharmaceutical Industries:
In pharmaceutical industries, 5-Iodo-2-methylbenzofuran is used as a building block for the development of new drugs. Its potential biological and pharmacological activities offer opportunities for the creation of innovative therapeutic agents and contribute to the advancement of medicine.

Upstream product

• 1745-81-9 o-Allylphenol 
• 59152-49-7 2-(iodomethyl)-2,3-dihydro-1-benzofuran 

Downstream Products

• 1206768-15-1 (S)-2-(2-methylbenzofuran-5-yl)-1-phenylpropan-1-one 

Relevant academic research and scientific papers

An efficient solid-phase synthesis of substituted benzofuran using selenium-bound resin

A very efficient solid-phase synthesis of substituted benzofuran using polymer-supported selenium resin is described. The advantages of the new method are good yields, high purity, straightforward operations, broad range and high diversity of products, lack of odor, and good stability of the resins. The easy work-up procedure makes the method suitable for building parallel libraries.

Bicyclic aromatic substituted pyridone derivative

Disclosed is a compound represented by the formula (I): Wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like; X1, X2 and X3 independently represent a methine group or a nitrogen atom; Y1 and Y3 independently represent a single bond, —O— or the like; Y2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z1 and Z2 independently represent a single bond, a C1-4 alkylene group or the like; Ar1 represents an aromatic carbocyclic ring or the like; and Ar2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

BICYCLIC AROMATIC SUBSTITUTED PYRIDONE DERIVATIVE

Disclosed is a compound represented by the formula (I): wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like; X1, X2 and X3 independently represent a methine group or a nitrogen atom; Y1 and Y3 independently represent a single bond, -O- or the like; Y2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methlene group or the like; L represents a single bond, a methylene group or the like; Z1 and Z2 independently represent a single bond, a C1-4 alkylene group or the like; Ar1 represents an aromatic carbocyclic ring or the like; and Ar2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

Synthesis of 5-iodobenzofurans and 6-iodobenzopyrans via direct iodination with mercury(II) oxide-iodine reagent

A tin(IV) chloride assisted iodo-cyclization of 2-allylphenol gave 2-iodomethyl-2,3-dihydrobenzofuran. A similar cyclization of 2-crotylphenol gave 3-iodo-2-methyl-3,4-dihydro-2H-benzopyran, exclusively. By iodination with mercury(II) oxide-iodine reagent in dichloromethane, 2,3-dihydrobenzofurans or 3,4-dihydro-2H-benzopyrans including the above benzocyclic ethers were easily converted to the corresponding 5- or 6-iodo derivatives, regioselectively, in good yield.