607721-72-2

Basic information

• Product Name: 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one
• Synonyms: 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one
• CAS NO: 607721-72-2
• Molecular Weight: 330.386
• Mol File: 607721-72-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one(607721-72-2)
• EPA Substance Registry System: 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methylsulfanyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one(607721-72-2)

Safety Data

• Hazardous Substances Data: 607721-72-2(Hazardous Substances Data)

Upstream product

• 306-37-6 N,N'-Dimethylhydrazine dihydrochloride 
• 503071-67-8 2-(4-fluorophenyl)-3-oxo-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester 
• 503071-70-3 2-(4-fluorophenyl)-3-hydroxy-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester 
• 1074-68-6 4-formyl-2-(methylthio)pyrimidine 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 73664-86-5 1,2-dimethylhydrazine hydrochloride 

Downstream Products

• 607721-73-3 4-(4-fluorophenyl)-1,2-dimethyl-5-(2-methanesulfonyl-pyrimidin-4-yl)-1,2-dihydropyrazol-3-one 

Relevant articles and documents

The development of monocyclic pyrazolone based cytokine synthesis inhibitors

4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of these inhibitors showed low nanomolar activity against LPS-induced TNF-α production. One of the compounds (6e) was found to be efficacious in the rat iodoacetate (RIA) in vivo model of osteoarthritis. The X-ray crystal structure of a pyrazolone inhibitor cocrystallized with mutated p38 (mp38) is presented.