607723-64-8

Basic information

• Product Name: 2-chloro-4-(phenylamino)pyridine
• Synonyms: 2-chloro-4-(phenylamino)pyridine
• CAS NO: 607723-64-8
• Molecular Weight: 204.659
• Mol File: 607723-64-8.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(phenylamino)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(phenylamino)pyridine(607723-64-8)
• EPA Substance Registry System: 2-chloro-4-(phenylamino)pyridine(607723-64-8)

Safety Data

• Hazardous Substances Data: 607723-64-8(Hazardous Substances Data)

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 62-53-3 aniline 
• 142-04-1 aniline hydrochloride 
• 23056-36-2 2-chloro-4-nitropyridine 

Downstream Products

• 607723-82-0 2-[methyl[4-(phenylamino)pyridin-2-yl]amino]ethanol 
• 607724-00-5 4-[2-[methyl[4-(phenylamino)pyridin-2-yl]amino]ethoxy]benzaldehyde 

Relevant articles and documents

Selective Functionalization of Aminoheterocycles by a Pyrylium Salt

The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.

Highly regioselective Buchwald-Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald-Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides facile access to 4-chl

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their biological activities, 5-(4-{2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy} benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.