60780-83-8Relevant academic research and scientific papers
APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 53; 54, (2018/12/02)
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
EFFECT OF SUBSTITUENTS ON CHEMICAL SHIFT OF PROTONS OF THE AMINO GROUP IN PMR SPECTRA OF SUBSTITUTED AMINOPYRIDINES
Shkurko, O. P.,Mamaev, V. P.
, p. 47 - 52 (2007/10/02)
The effect of substituents on the chemical shift of the protons of the amino group in six series of m- and p-substituted 2-, 3- and 4-aminopyridines (in DMSO) was studied by correlation analysis using the inductive and resonance constants.The peculiarities of the pyridine ring in the transmission of the electronic effects of the substituents are discussed.
