60781-83-1

Basic information

• Product Name: 4-PHENYL-PYRIDIN-2-YLAMINE
• Synonyms: 4-PHENYL-PYRIDIN-2-YLAMINE;2-AMINO-4-PHENYLPYRIDINE;4-phenyl-2-pyridinamin;4-phenyl-2-aminopyridine;4-Phenyl-2-pyridinamine;4-Phenylpyridine-2-amine;2-Pyridinamine, 4-phenyl-;4-phenylpyridin-2-amine
• CAS NO: 60781-83-1
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• Product Categories: API intermediates
• Mol File: 60781-83-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 164-165 °C(Solv: benzene (71-43-2))
• Boiling Point: 343.678 °C at 760 mmHg
• Flash Point: 188.447 °C
• Appearance: /
• Density: 1.133g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.63±0.11(Predicted)
• CAS DataBase Reference: 4-PHENYL-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-PYRIDIN-2-YLAMINE(60781-83-1)
• EPA Substance Registry System: 4-PHENYL-PYRIDIN-2-YLAMINE(60781-83-1)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 60781-83-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 21, p. 874, 1978 DOI: 10.1021/jm00207a007The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Upstream product

• 1131-61-9 4-Phenylpyridine 1-oxide 
• 1120-87-2 4-bromopyridin 
• 98-80-6 phenylboronic acid 
• 84249-14-9 2-amino-4-bromopyridine 
• 405939-28-8 (4-iodopyridin-2-yl)carbamic acid tert-butyl ester 
• 622402-25-9 tert-butyl (4-phenylpyridin-2-yl)carbamate 
• 74405-01-9 2,2-Dimethyl-3-(4-phenyl-pyridin-2-yl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one; hydrochloride 
• 939-23-1 p-phenylpyridine 

Downstream Products

• 54151-74-5 2-bromo-4-phenylpyridine 
• 85102-27-8 7-phenylimidazo[1,2-a]pyridine 
• 911717-61-8 1-[(4-phenylpyridin-2-yl)amino]cyclohexanecarboxylic acid 
• 622402-28-2 7-phenyl-3-pyridin-4-yl-imidazo[1,2-a]pyridine 
• 622402-26-0 3-iodo-7-phenyl-imidazo[1,2-a]pyridine 
• 81560-17-0 1,3-bis(2'-(4'-phenyl)pyridylimino)isoindoline 

Relevant articles and documents

Mild, General, and Regioselective Synthesis of 2-Aminopyridines from Pyridine N -Oxides via N -(2-Pyridyl)pyridinium Salts

A synthesis of 2-aminopyridines from pyridine N-oxides via their corresponding N-(2-pyridyl)pyridinium salts has been demonstrated and investigated. The reaction sequence features a highly regioselective conversion of the N-oxide into its pyridinium salt

UREA DERIVATIVES AS CB1 ALLOSTERIC MODULATORS

Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1 R) allosteric modulators of formula (I) are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the analogs to treat

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.