60782-31-2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 54722-52-0 2-amino-3-phenyl-3H-indol-3-ol 
• 100-58-3 phenylmagnesium bromide 
• 60782-29-8 2,3,4,5-tetrahydro-[1,3]diazepino[1,2-a]indol-11-one 

Downstream Products

• 136650-35-6 7-phenyl-2,3,4,5,6,7-hexahydro-1H-1,7-methano-1,6-benzodiazonine-12-one 
• 114918-69-3 11-acetamido-2,3,4,5-tetrahydro-11-phenyl-11H-<1,3>diazepino<1,2-a>indole 
• 136650-37-8 7-phenyl-6-(p-tolylsulphonyl)-2,3,4,5,6,7-hexahydro-1H-1,7-methano-1,6-benzodiazonin-12-one 

Relevant academic research and scientific papers

Diazepino[1,2-α]indoles

This invention relates to bases of the formula SPC1 And their acid addition salts with pharmaceutically acceptable acids. In the formula R1 represents phenyl or phenyl substituted by one or more hydroxyl, lower alkyl, lower alkoxy, haloloweralkyl or halogen atoms; R2 and R5 are hydrogen, hydroxyl, lower alkyl, lower alkoxy, haloloweralkyl or halogen and R3 and R4 are hydrogen or lower alkyl. The compounds have antidepressant activity.

Process for the preparation of diazepino[1,2-a]indoles

The invention relates to a process for preparing fused ring indole derivatives of formula (I) SPC1 wherein R1, R2, R3, R4 are each hydrogen, hydroxyl, lower alkyl, lower alkoxy, haloloweralkyl or halogen, R5 and R6 are each hydrogen or lower alkyl and m and n are 0, 1, 2 or 3 and the sum of m + n is 2 or 3, by condensing an indole derivative of formula SPC2 With a dihaloalkane of formula EQU1 The products have pharmacological activity, particularly antidepressant and hypoglycaemic activity.