60783-85-9

Upstream product

• 62-53-3 aniline 
• 705-62-4 N,N-dimethyl-N'-phenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 20939-15-5 3-methyl-4-amino-5-mercapto-1,2,4-triazole 

Downstream Products

• 86671-57-0 (3-Methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)-phenyl-amine 

Relevant academic research and scientific papers

Use of tetramethylthiuram disulfide in synthesis of nitrogen-containing heterocyclic compounds

We have developed a method for synthesis of aryl isothiocyanates by means of thiocarbamoylation of aromatic amines by tetramethylthiuram disulfide followed by degradation of the intermediate N(1)-aryl-N,N- dimethylthiourea by concentrated HCl. We have shown that thiocarbamoylation of 4-amino-5-ethyl-4H-1,2,4-triazole-3-thiol occurs at the 2 position of the triazole ring, while thiocarbamoylation of 4-amino-3-methyl-6-phenyl-4,5- dihydro-1,2,4-triazin-5-one leads to the dihetaryl-substituted thiourea. We consider the possibility of using N(1)-aryl-N,N-dimethylthioureas as analogs of isothiocyanates in reactions with N-nucleophiles. 2005 Springer Science+Business Media, Inc.