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1-(2-Chloroethyl)-3-(4-hydroxybutyl)-1-nitrosourea, also known as Nimustine or ACNU, is a chemotherapy agent with alkylating properties. It is a nitrosourea derivative that exerts its antitumor effects by crosslinking DNA, which ultimately inhibits DNA and RNA synthesis. Nimustine is lipophilic and can penetrate the blood-brain barrier, making it particularly effective in the treatment of brain tumors.

60784-48-7

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60784-48-7 Usage

Uses

Used in Anticancer Applications:
1-(2-Chloroethyl)-3-(4-hydroxybutyl)-1-nitrosourea is used as an anticancer agent for its potent antitumor effects against various types of cancer, including brain tumors, lymphomas, and lung cancer. Its ability to crosslink DNA and inhibit nucleic acid synthesis contributes to its effectiveness in treating these malignancies.
Used in Pharmaceutical Industry:
1-(2-Chloroethyl)-3-(4-hydroxybutyl)-1-nitrosourea is used as a key component in the development of chemotherapy drugs due to its alkylating properties and its effectiveness in treating certain types of cancer. Its lipophilic nature and ability to penetrate the blood-brain barrier make it a valuable asset in the pharmaceutical industry for the creation of targeted cancer treatments.
Common side effects of Nimustine include myelosuppression, nausea, vomiting, and alopecia. It is typically administered intravenously under the supervision of a healthcare professional. Due to its potent antitumor effects and potential toxicities, Nimustine should only be used under the guidance of a qualified oncologist.

Check Digit Verification of cas no

The CAS Registry Mumber 60784-48-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,8 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 60784-48:
(7*6)+(6*0)+(5*7)+(4*8)+(3*4)+(2*4)+(1*8)=137
137 % 10 = 7
So 60784-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H14ClN3O3/c8-3-5-11(10-14)7(13)9-4-1-2-6-12/h12H,1-6H2,(H,9,13)

60784-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-chloroethyl)-3-(4-hydroxybutyl)-1-nitrosourea

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:60784-48-7 SDS

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