608128-76-3Relevant academic research and scientific papers
Magnesium-coordinated chelation control in 1,3-dipolar cycloaddition of chiral α-alkoxymethyl ether nitrile oxide: Application to the synthesis of (-)/(-)- cis -clausenamide
Tanda, Kazuhiro,Toyao, Atsushi,Watanabe, Akiko,Sakamoto, Masanori,Yamasaki, Tetsuo
, (2014)
A facile regio- and diastereoselective nitrile oxide cycloaddition method using magnesium-coordinated chelation control of chiral α-alkoxymethyl ether nitrile oxide is reported. This reaction could be successfully applied as a key step in both the formal total synthesis of (-)-clausenamide and the total synthesis of (-)-cis-clausenamide.
Concise asymmetric synthesis of fully substituted isoxazoline-N-Oxide through lewis base catalyzed nitroalkene activation
Zhong, Cheng,Gautam, Lekh Nath S.,Petersen, Jeffrey L.,Akhmedov, Novruz G.,Shi, Xiaodong
supporting information; experimental part, p. 8605 - 8609 (2010/11/03)
(Figure Presented) Transforming isoxazoline-N-oxides: A concise asymmetric synthesis of isoxazoline-N-oxides is reported through secondary amine Lewis base catalyzed nitroalkene activation and sequential intermolecular condensation with aldehydes and ylides. Application of camphor-derived chiral sulfur ylides gave the enantiomeric-enriched isoxazolineN-oxides in excellent yields and stereoselectivity. Simple transformations of isoxazoline-N-oxide led to the gramscale synthesis of a (-)-clausenamide analogue in four steps, with excellent stereochemistry control (see scheme).
Synthesis and activity in enhancing long-term potentiation (LTP) of clausenamide stereoisomers
Feng, Zhiqiang,Li, Xingzhou,Zheng, Guojun,Huang, Liang
scheme or table, p. 2112 - 2115 (2009/12/03)
Clausenamide, isolated from aqueous extract of dry leaves of Clausena lansium, a Chinese folk medicine, was found to have potent activity in enhancing LTP and show nootropic activity in animal tests. In order to discovery more potent stereoisomers and to
