608128-77-4Relevant academic research and scientific papers
Diastereoselective Addition of Prochiral Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines
Ando, Kaori,Fettinger, James,Gutierrez, David A.,Houk, K. N.,Shaw, Jared T.
, p. 1164 - 1168 (2022/02/14)
The Lewis-acid-promoted addition of prochiral E- and Z-allyl nucleophiles to chiral α-alkoxy N-tosyl imines is described. Alkene geometry is selectively transferred to the newly formed carbon-carbon bond, resulting in stereochemical control of C1, C2, and C3 of the resulting 2-alkoxy-3-N-tosyl-4-alkyl-5-hexene products. A computational analysis to elucidate the high selectivity is also presented. This methodology was employed in the synthesis of two naturally occurring isomers of clausenamide.
Synthesis and activity in enhancing long-term potentiation (LTP) of clausenamide stereoisomers
Feng, Zhiqiang,Li, Xingzhou,Zheng, Guojun,Huang, Liang
scheme or table, p. 2112 - 2115 (2009/12/03)
Clausenamide, isolated from aqueous extract of dry leaves of Clausena lansium, a Chinese folk medicine, was found to have potent activity in enhancing LTP and show nootropic activity in animal tests. In order to discovery more potent stereoisomers and to
