6084-54-4

Basic information

• Product Name: 1-(AMMONIOOXY)PROPANE CHLORIDE
• Synonyms: 1-(AMINOOXY)PROPANE HYDROCHLORIDE;1-(AMMONIOOXY)PROPANE CHLORIDE;AMinoxypropane hydrochloride;O-Propylhydroxylamine hydrochloride;Propoxyamine hydrochloride
• CAS NO: 6084-54-4
• Molecular Formula: C₃H₉NO*ClH
• Molecular Weight: 111.57
• Mol File: 6084-54-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 148-152°C
• Boiling Point: 153.2°C at 760 mmHg
• Flash Point: 46.4°C
• Appearance: /
• Vapor Pressure: 2.98mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(AMMONIOOXY)PROPANE CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(AMMONIOOXY)PROPANE CHLORIDE(6084-54-4)
• EPA Substance Registry System: 1-(AMMONIOOXY)PROPANE CHLORIDE(6084-54-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6084-54-4(Hazardous Substances Data)

Usage

General Description

1-(Ammoniooxy)propane chloride, also known as AOPC, is a quaternary ammonium compound used as a surfactant and antistatic agent in various industrial and household products. It is synthesized by reacting ammonium hydroxide with 3-chloropropyltrimethoxysilane, resulting in a cationic surfactant with positively charged ammonium groups. AOPC is widely used in the manufacturing of hair conditioners, fabric softeners, and other personal care products to impart a soft and smooth texture to surfaces. Additionally, it is used in the production of antistatic agents for plastics and coatings to reduce the buildup of static electricity. AOPC is known for its strong cationic properties and is considered an effective and versatile chemical in various applications.

InChI:InChI=1/C3H9NO.ClH/c1-2-3-5-4;/h2-4H2,1H3;1H

Upstream product

• 42832-43-9 N-Acetyl-O-propyl-hydroxylamin 
• 51951-26-9 N-propoxyphthalimide 
• 5792-43-8 O-n-propylhydroxylamine 
• 64648-16-4 N-propoxybenzamide 

Downstream Products

• 851181-14-1 3-propyloxyimino-2-(4-hydroxy-benzyl)-butyric acid methyl ester 
• 1394013-76-3 C₁₄H₁₉NO₄ 
• 1394013-83-2 C₁₄H₁₉NO₄ 
• 888707-62-8 C₁₄H₁₉NO₄ 
• 1262055-58-2 (E)-1-cyclohexyl-3-(1-(propoxyamino)ethylidene)pyrrolidine-2,4-dione 

Relevant articles and documents

Design, synthesis and evaluation of wound healing activity for β-sitosterols derivatives as potent Na+/K+-ATPase inhibitors

β-Sitosterols, is a common steroid that can be identified in a variety of plants and their efficacy in promoting wound healing has been demonstrated. Na+/K+-ATPase, more than a pump, its signal transduction function for involvement in cell growth regulation attracts widespread concern. The Na+/K+-ATPase/Src receptor complex can serve as a receptor involved in multiple signaling pathways including promoting wound healing pathways. To finding potent accelerating wound healing small molecular, we choose the high inhibitory activity of Na+/K+-ATPase and non-cardiotoxic natural compound, β-sitosterol as the substrate. A series of β-sitosterol derivatives were designed, synthesized and evaluated as potential Na+/K+-ATPase inhibitors. Among them, compounds 31, 47, 49, showed improved inhibitory activity on Na+/K+-ATPase, with IC50 value of 3.0 μM, 3.4 μM, 2.2 μM, which are more potent than β-sitosterol with IC50 7.6 μM. Especially, compound 49 can induce cell proliferation, migration and soluble collagen production in L929 fibroblasts. Compared to model, compound 49 can accelerate wound healing in SD rats. Further studies indicated that 49 can activate the sarcoma (Src), uptake the protein kinase B (Akt), extracellular signal-regulated kinase (ERK) proteins expression in a concentration dependent manner. Finally, binding mode of compound 49 with Na+/K+-ATPase was studied, which provides insights into the determinants of potency and selectivity. These results proved β-stitosterol derivative 49 can serve as an effective inhibitor of Na+/K+-ATPase and potential candidate for accelerating wound healing agents.

Sterol derivatives and its preparation method and application

The invention discloses a sterol derivative of beta-sitosterol, beta-stigmasterol and cholesterol, and is shown as a formula VI. The invention also discloses a preparation method of the sterol derivative. The invention also discloses application of the sterol derivative to the aspect of preparation of wound healing promoting medicine. By starting from easily obtained natural products, the beta-sitosterol, the beta-stigmasterol and the cholesterol are used as starting raw materials; the synthetic method is simple; better operability and reaction yield are realized. The prepared sterol derivative has the obvious wound healing promoting activity; the multiplication, migration and collagen synthesis capability on L929 mechanocytes is obviously higher than that of the raw material and positive control medicine recombinant human bFGF (basic fibroblast growth factor). Compared with protide type medicine (such as bFGF), the prepared sterol derivative has more diversified dosage forms and medication modes; the reference is provided for the application in the field of wound healing promoting. The formula VI is shown as the accompanying diagram.

NOVEL VASCULAR LEAKAGEAGE INHIBITOR

The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present invention inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, and enhances the cortical actin ring structure, thereby inhibiting vascular leakage. Accordingly, the vascular leakage inhibitor of the present invention can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present invention is synthesized from commercially available or easily synthesizable pregnenolones, it has remarkably superior feasibility of commercial synthesis.