608489-48-1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 608489-55-0 3-((3aS,5aS,6R,9aR,9bS)-3,3,7,7-Tetramethoxy-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-6-yl)-propan-1-ol 
• 83543-81-1 methyl 5,17-dioxo-A-nor-3,4-seco-androstan-3-oate 

Relevant academic research and scientific papers

Magnetic shielding effect of amine and ammonium groups obtained from proton chemical shifts of androstane derivatives

4-Aza-5α-androstanone(1α) and 4-aza-5β-androstanone(1β) were synthesized in order to obtain the NMR shielding parameters for the secondary amine group. A combination of the electric field effect and the anisotropy of the magnetic susceptibility of the C-N bond can successfully reproduce the observed SIS values for these androstanes. Drastic chemical shift change of protons near-by nitrogen atom of ammonium salt was observed and shielding parameter for the secondary ammonium group was also obtained.