60851-83-4Relevant academic research and scientific papers
Oxidation of Luminol by Chlorine Dioxide. Formation of 4-Aminophtalazine-1,4-dione
Eriksen, Trygve E.,Lind, Johan,Merenyi, Gabor
, p. 2125 - 2136 (1981)
The pH-dependent rection rate between luminol and chlorine dioxide has been determined.The net oxidation reaction proceeds in two steps.The first of these is the formation of a luminol-ClO2 adduct.This adduct, which is unreactive towards oxygen, reacts rapidly with itself or with a second ClO2 molecule.The final product has a broad absorbance between 450 and 650 nm.An identical absorbance is produced when luminol is oxidized by HOCl.The species displaying this absorbance is very reactive towards OH- and undissociated luminol.In the presence of hydrogen peroxide and pH > 7 the absorbance disappears.At the same time an intense chemiluminescence is observed, the decay of which is quantitatively in agreement with the decay of the 450-650 nm absorbance.From these findings it is concluded that the oxidation product of luminol with ClO2 is 5-aminophtalazine-1,4-dione.
A Common, Facile and Eco-Friendly Method for the Reduction of Nitroarenes, Selective Reduction of Poly-Nitroarenes and Deoxygenation of N-Oxide Containing Heteroarenes Using Elemental Sulfur
Cerecetto, Hugo,Romero, Angel H.
supporting information, (2020/03/23)
A transition metal-free, environment-friendly and practical protocol was developed either for the reduction of nitroarenes or for the deoxygenation of N-oxide containing heteroarenes. The reaction proceeded with the use of a non-toxic and cheap feedstock as elemental sulfur in aqueous methanol under relatively mild conditions. Green chemistry credentials were widely favorable compared to traditional and industrial protocols with good E-factors and a low production of waste. The strategy allowed the efficient reduction of a large variety of substituted-nitroarenes including various o-nitroanilines as well as selective reduction of various poly-nitroarenes in excellent yields with a broad substrate scope. The protocol was successfully extended to the deoxygenation of some N-oxide containing heteroarenes, like benzofuroxans, phenazine N,N'-dioxides, pyridine N-oxides, 2H-indazole N1-oxides, quinoxaline N1,N4-dioxides and benzo[d]imidazole N1,N3-dioxides. A gram-scale example for the synthesis of luminol, in green conditions, was reported. A solid mechanism of reaction was proposed from experimental evidences.
DPPH·–luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis
Yao, Hong,Huang, Xiaomei,Shi, Peiying,Lin, Zhen,Zhu, Meilan,Liu, Ailin,Lin, Xinhua,Tang, Yuhai
, p. 588 - 595 (2017/05/15)
In this article, a DPPH·–luminol chemiluminescence (CL) system was reported and the CL mechanism was discussed according to the CL kinetic properties after sequence injecting DPPH· into the DPPH·–luminol reaction mixture. It was observed that scutellarin could inhibit the CL response of the DPPH·–luminol system. Based on this observation, a simple and rapid flow injection CL method was developed for the determination of scutellarin using the inhibition effect in alkaline medium. The optimized chemical conditions for the CL reaction were 5?×?10?6?mol/L DPPH· and 1.0?×?10?4?mol/L luminol in 0.01?mol/L NaOH. Under optimized conditions, the CL intensity was inversely proportional to the concentration of scutellarin over the ranges 5–2000 and 40–3200?ng/ml in pharmaceutical injection and rat plasma, respectively. The limits of detection (S/N?=?3) were 5 and 40?ng/ml in preparations and rat plasma, respectively. Furthermore, the precision, recovery and stability of the validated method were acceptable for the determination of scutellarin in both pharmaceutical injections and rat plasma. The presented method was successfully applied in the determination of scutellarin in pharmaceutical injections and real rat plasma samples.
The Equilibrium Reaction of the Luminol Radical with Oxygen and the One-Electron-Reduction Potential of 5-Aminophthalazine-1,4-dione
Merenyi, Gabor,Lind, Johan,Eriksen, Trygve E.
, p. 2320 - 2323 (2007/10/02)
The kinetics of the redox reaction of one-electron-oxidized luminol with molecular oxygen has been studied with chemiluminescent techniques.The rate constants of the forward and reverse reactions have been determined to be 550 +/- 100 and (2.5 +/- 1.6)E9 M-1s-1, respectively.These values afforded the one-electron-reduction potential of 5-aminophthalazine-1,4-dione with E0 = 240 +/- 20 mV vs.NHE.
Role of a Peroxide Intermediate in the Chemiluminescence of Luminol. A Mechanistic Study
Merenyi, Gabor,Lind, Johan S.
, p. 5830 - 5835 (2007/10/02)
By simultaneous generation of the luminol radical and the superoxide radical anion O2-. in an alkaline aqueous solution containing H2O2 but no oxygen, it was possible to measure at different pH values the rate constant for the format
