60851-83-4

Basic information

• Product Name: 5-aminophthalazine-1,4-dione
• CAS NO: 60851-83-4
• Molecular Formula: C₈H₅N₃O₂
• Molecular Weight: 175.1442
• Mol File: 60851-83-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 409.9°C at 760 mmHg
• Flash Point: 201.7°C
• Density: 1.66g/cm³
• Vapor Pressure: 6.26E-07mmHg at 25°C
• Refractive Index: 1.779
• CAS DataBase Reference: 5-aminophthalazine-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aminophthalazine-1,4-dione(60851-83-4)
• EPA Substance Registry System: 5-aminophthalazine-1,4-dione(60851-83-4)

Safety Data

• Hazardous Substances Data: 60851-83-4(Hazardous Substances Data)

Upstream product

• 521-31-3 5-amino-2,3-dihydrophthalazine-1,4-dione 
• 521-31-3 luminol 
• 89596-65-6 luminol radical 
• 3682-15-3 5-nitro-2,3-dihydro-phthalazine-1,4-dione 

Downstream Products

• 27846-29-3 3-aminophthalate dianion 
• 521-31-3 5-amino-2,3-dihydrophthalazine-1,4-dione 

Relevant articles and documents

Oxidation of Luminol by Chlorine Dioxide. Formation of 4-Aminophtalazine-1,4-dione

The pH-dependent rection rate between luminol and chlorine dioxide has been determined.The net oxidation reaction proceeds in two steps.The first of these is the formation of a luminol-ClO2 adduct.This adduct, which is unreactive towards oxygen, reacts rapidly with itself or with a second ClO2 molecule.The final product has a broad absorbance between 450 and 650 nm.An identical absorbance is produced when luminol is oxidized by HOCl.The species displaying this absorbance is very reactive towards OH- and undissociated luminol.In the presence of hydrogen peroxide and pH > 7 the absorbance disappears.At the same time an intense chemiluminescence is observed, the decay of which is quantitatively in agreement with the decay of the 450-650 nm absorbance.From these findings it is concluded that the oxidation product of luminol with ClO2 is 5-aminophtalazine-1,4-dione.

DPPH·–luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis

In this article, a DPPH·–luminol chemiluminescence (CL) system was reported and the CL mechanism was discussed according to the CL kinetic properties after sequence injecting DPPH· into the DPPH·–luminol reaction mixture. It was observed that scutellarin could inhibit the CL response of the DPPH·–luminol system. Based on this observation, a simple and rapid flow injection CL method was developed for the determination of scutellarin using the inhibition effect in alkaline medium. The optimized chemical conditions for the CL reaction were 5?×?10?6?mol/L DPPH· and 1.0?×?10?4?mol/L luminol in 0.01?mol/L NaOH. Under optimized conditions, the CL intensity was inversely proportional to the concentration of scutellarin over the ranges 5–2000 and 40–3200?ng/ml in pharmaceutical injection and rat plasma, respectively. The limits of detection (S/N?=?3) were 5 and 40?ng/ml in preparations and rat plasma, respectively. Furthermore, the precision, recovery and stability of the validated method were acceptable for the determination of scutellarin in both pharmaceutical injections and rat plasma. The presented method was successfully applied in the determination of scutellarin in pharmaceutical injections and real rat plasma samples.

Role of a Peroxide Intermediate in the Chemiluminescence of Luminol. A Mechanistic Study

By simultaneous generation of the luminol radical and the superoxide radical anion O2-. in an alkaline aqueous solution containing H2O2 but no oxygen, it was possible to measure at different pH values the rate constant for the format