608512-87-4

Basic information

• Product Name: FMOC-D-SER(AC)-OH
• Synonyms: FMOC-O-ACETYL-D-SERINE;FMOC-D-SER(AC)-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-ACETYL-D-SERINE;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-serine acetate (ester);Fmoc-O-acetyl-D-serine≥ 97% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Ser(Ac)-OH
• CAS NO: 608512-87-4
• Molecular Formula: C20H19NO6
• Molecular Weight: 369.37
• Mol File: 608512-87-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0°C
• Solubility: DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: FMOC-D-SER(AC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-SER(AC)-OH(608512-87-4)
• EPA Substance Registry System: FMOC-D-SER(AC)-OH(608512-87-4)

Safety Data

• Hazardous Substances Data: 608512-87-4(Hazardous Substances Data)

Usage

Uses

Fmoc-D-ser(Ac)-OH (cas# 608512-87-4) is a compound useful in organic synthesis.

Upstream product

• 31077-89-1 1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranose 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 5147-00-2 O-acetyl-L-serine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Synthesis method of Na-9-fluorenylmethoxycarbonyl-O-acetyl-L-serine

The invention relates to a synthesis method of Na-9-fluorenylmethoxycarbonyl-O-acetyl-L-serine, mainly aiming at solving the technical problems that in the existing synthesis method, the aftertreatment operation is more troublesome since perchloric acid is taken as a catalyst, excessive acetyl chloride is used, and potential safety hazard is caused when ethyl ether is used for crystallizing. The method comprises the following steps: (1) dissolving solid L-serine into an acetic acid solution, dropwise adding liquid acetyl chloride, and stirring for carrying out reaction; adding the reaction liquid into a petroleum ether solution, separating out an intermediate O-acetyl-L-serine, filtering and drying; (2) dissolving the intermediate into a sodium carbonate solution, dropwise adding a 9-fluorene methyl-N-succinimido-carbonate solution dissolved in ethyl acetate, removing the excessive 9-fluorene methyl-N-succinimido-carbonate in a layering way, acidifying the water phase by using hydrochloric acid, then extracting by using an extracting agent-ethyl acetate, washing the obtained oil phase with water, removing the hydrochloric acid, and concentrating the oil phase for removing the extracting agent-ethyl acetate so as to obtain the white crystal Na-9-fluorenylmethoxycarbonyl-O-acetyl-L-serine product. The product synthesized by the method is an important raw material for synthesizing polypeptide drugs.