608520-05-4Relevant articles and documents
Solid-Phase Total Synthesis of Dehydrotryptophan-Bearing Cyclic Peptides Tunicyclin B, Sclerotide A, CDA3a, and CDA4a using a Protected β-Hydroxytryptophan Building Block
Diamandas, Matthew,Moreira, Ryan,Taylor, Scott D.
, p. 3048 - 3052 (2021)
A new approach to the synthesis of Z-dehydrotryptophan (ΔTrp) peptides is described. This approach uses Fmoc-β-HOTrp(Boc)(TBS)-OH as a building block, which is readily prepared in high yield and incorporated into peptides using solid-phase Fmoc chemistry. The tert-butyldimethylsilyl-protected indolic alcohol is eliminated during global deprotection/resin cleavage to give ΔTrp peptides exclusively as the thermodynamically favored Z isomer. This approach was applied to the solid-phase synthesis of tunicyclin B, sclerotide A, CDA3a, and CDA4a.
SYNTHESIS OF AN INTERMEDIATE OF AN ANTIVIRAL COMPOUND
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Paragraph 0107; 0108, (2014/06/11)
Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.
Synthesis of an intermediate of an antiviral compound
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Paragraph 0092-0093, (2014/06/24)
Process for the preparation of a cyclopropylamide compound (II) which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.
First one-pot copper-catalyzed synthesis of α-hydroxy-β-amino acids in water. A new protocol for preparation of optically active norstatines
Fringuelli, Francesco,Pizzo, Ferdinando,Rucci, Mauro,Vaccaro, Luigi
, p. 7041 - 7045 (2007/10/03)
α-Hydroxy-β-amino acids were synthesized with excellent yields for the first time in water and by a simple procedure based on a copper catalytic cycle, which included the recovery and reuse of the catalyst and is possible to realize by using only water as reaction medium.