608525-74-2Relevant academic research and scientific papers
Concise Formal Synthesis of (-)-Peduncularine via Ring-Closing Metathesis
Washburn, David G.,Heidebrecht Jr., Richard W.,Martin, Stephen F.
, p. 3523 - 3525 (2003)
Equation presented. A synthesis of the 6-aza[3.2.1]bicyclooctene (-)-2 has been completed by a short sequence of reactions that required only six operations from (S)-malic acid and featured a novel ring-closing metathesis to form the bridged bicyclic ring. Because 2 was previously converted into (-)-peduncularine (1), its preparation constitutes a formal enantioselective synthesis of 1.
