608527-93-1Relevant articles and documents
Total synthesis of merrilactone A
Inoue, Masayuki,Sato, Takaaki,Hirama, Masahiro
, p. 10772 - 10773 (2003)
Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. In this paper, we report the total synthesis of (±)-1, employing, as key steps, a novel desymmetrization protocol of meso-diketone to construct the core cis-bicyclo[3.3.0]octyl system of 1 (3 → 2) and a radical cyclization to install the highly congested C9-quaternary carbon (16 → 17). Copyright