608533-83-1

Basic information

• Product Name: (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
• Synonyms: (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
• CAS NO: 608533-83-1
• Molecular Weight: 391.406
• Mol File: 608533-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester(608533-83-1)
• EPA Substance Registry System: (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester(608533-83-1)

Safety Data

• Hazardous Substances Data: 608533-83-1(Hazardous Substances Data)

Upstream product

• 79815-19-3 methyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 
• 1499-21-4 Diphenylphosphinic chloride 

Downstream Products

• 608533-90-0 (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 608533-88-6 (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ((S)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 608533-96-6 (S)-2-(Diphenyl-phosphinoyl)-3-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline 
• 608533-98-8 (S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline 
• 608533-86-4 (S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid 

Relevant articles and documents

Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation

Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate.