60889-30-7

Upstream product

• 100-46-9 benzylamine 
• 1256106-48-5 (1-benzylpyrrolidine-3,4-diyl)dimethanol 
• 607362-87-8 1-benzyl-pyrrolidine-3,4-dicarboxylic acid dimethyl ester 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 

Downstream Products

• 60889-32-9 hexahydro-1H-furo(3,4-c)-pyrrole 
• 1438075-28-5 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine 

Relevant academic research and scientific papers

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

2-PHENYL-5-HETEROCYCLYL-TETRAHYDRO-2H-PYRAN-3-AMINE COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND ITS ASSOCIATED DISORDERS

The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment or prevention of diabetes mellitus (DM), obesity and other metabolic disorders. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain

Diclosed are compounds, having the following general formula, which are useful as analgesics and/or anti-inflammatory agents in living animals SPC1 Wherein R is a radical selected from the group consisting of hydrogen, aryl, alkenyl, aralkyl, halogen-substituted aralkyl, hydroxyl-substituted alkyl, arylsulfonyl, alicyclic, aroyl, alkylene dicarbonyl hexahydro-1H-furo (3,4-c)pyrrole, alkanoyl, arylene dicarbonyl hexahydro-1H-furo(3,4-c)pyrrole, halogen-substituted aroyl, arylethanoyl, halogen-substituted arylalkanoyl, halogen-substituted phenoxyalkanoyl, heteroaroyl, haloalkyl-substituted aroyl, alkyl-substituted aroyl, monoalkoxy-substituted aroyl, arylalkenoyl, hexahydrobenzoyl, alkanoyloxy-substituted aroyl, hydroxyl-substituted aroyl, and the pharmacologically acceptable acid addition salts thereof.