60892-57-1

Basic information

• Product Name: 2-bromo-6beta-fluoro-21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate
• Synonyms: 2-bromo-6beta-fluoro-21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate;21-Acetoxy-2-bromo-6β-fluoropregna-1,4,9(11),16-tetrene-3,20-dione
• CAS NO: 60892-57-1
• Molecular Formula: C₂₃H₂₄BrFO₄
• Molecular Weight: 463.3366632
• EINECS: 262-516-4
• Mol File: 60892-57-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 579.5°C at 760 mmHg
• Flash Point: 304.3°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 2E-13mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-bromo-6beta-fluoro-21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6beta-fluoro-21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate(60892-57-1)
• EPA Substance Registry System: 2-bromo-6beta-fluoro-21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate(60892-57-1)

Safety Data

• Hazardous Substances Data: 60892-57-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H24BrFO4/c1-12(26)29-11-21(28)16-5-4-14-13-8-19(25)17-9-20(27)18(24)10-23(17,3)15(13)6-7-22(14,16)2/h5-6,9-10,13-14,19H,4,7-8,11H2,1-3H3/t13-,14-,19+,22-,23+/m0/s1

Relevant articles and documents

2-Bromo-6β-fluoro-3-keto-Δ1,4 -steroids of the pregnane series

Pregnane series steroids are disclosed having good anti-inflammatory and anti-rheumatoid arthritic activity with a decreased degree of side effects, e.g., weight loss and sodium retention. The compounds have the formula STR1 where X is a keto- or β-hydroxyl group or chlorine, Y is fluorine or chlorine, Z is hydrogen, α-hydroxyl, α-methyl or β-methyl, R' is hydrogen or a 2 to 8 carbon acyl group and R is hydrogen, a 2 to 8 carbon acyl group from mono- or di-carboxylic organic acids, a metasulfobenzoic acid residue or phosphoric acid residue. When R' is hydrogen, and Z is α-hydroxyl the corresponding 16α, 17α-acetonides and 16α-acyl derivatives with organic carboxylic acids having from 2 to 8 carbon atoms were prepared.