60907-89-3Relevant academic research and scientific papers
Method for synthesizing pesticide intermediate 2,4-dichloroacetophenone by recycling epoxypropane coproduct
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Paragraph 0033; 0034; 0035; 0036; 0037, (2019/01/21)
The invention belongs to the technical field of organic chemical industry, relates to a preparation method of a halogen-containing aromatic ketone organic compound 2,4-dichloroacetophenone, and concretely relates to a method for synthesizing an important pesticide intermediate 2,4-dichloroacetophenone, for an efficient bactericide propiconazole, a pesticide chlorfenvinphos and a herbicide difenzoquat, from alpha-methylbenzyl alcohol, co-produced through an ethylbenzene co-oxidation technology (PO/SM technology), by halogenation, chlorination, alkaline hydrolysis and oxidation reactions. The total yield is 85% or above, and the purity of the product is 99.7% or above. The method has the advantages of clean process, low raw material cost, high product purity, and easiness in industrialization realization.
ARYLALKANOIC ACID DERIVATIVE
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, (2008/06/13)
A compound represented by the formula (I): wherein Ar is an optionally substituted aromatic ring; Xa, Xc, Ya, Yc, Z1 and Z2 are each a bond, O, S, -CO-, -CS-, - CR3 (OR4) -, -NR5-, -SO-, -SO2-, -CONR6- or -NR6CO- (wherein R3, R4, R5 and R6 are as defined in the specification); Xb and Yb are each a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R1 is an optionally substituted hydrocarbon group; ring A is an optionally further substituted aromatic ring, provided that the ring should not be benzimidazole; n is an integer of 1 to 8; ring B is an optionally further substituted aromatic ring, provided that the ring should not be oxazole; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; and R2 is -OR8 or -NR9R10 (wherein R8, R9 and R10 are as defined in the specification) or a salt thereof, is useful as an agent for the prophylaxis or treatment of diabetes and the like.
ARYLALKANOIC ACID DERIVATIVE
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Page/Page column 117, (2010/11/08)
A compound represented by the general formula (I): [wherein Ar represents an optionally substituted aromatic ring; Xa, Xc, Ya, Yc, Z1, and Z2 each represents a bond, O, S, -CO-, -CS-, -CR3(OR4)-, -NR5-, -SO-, -SO2-, -CONR6-, or -NR6CO- (R3, R4, R5, and R6 are as defined in the description); Xb and Yb each represents a bond or a C1-20 divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; ring A represents an aromatic ring (other than benzimidazole) which may be further substituted; n is an integer of 1-8; ring B represents an aromatic ring (other than oxazole) which may be further substituted; W represents a C1-20 divalent saturated hydrocarbon group; and R2 represents -OR8 or -NR9R10 (R8, R9, and R10 are as defined in the description)] or a salt of the compound. It is useful as a preventive/therapeutic agent for diabetes, etc.
