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Eseramine, also known as N-[(1S)-1-(3,4-dimethoxyphenyl)ethyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-2-phenylethane-1,1-diamine, is a potent and selective serotonin reuptake inhibitor (SSRI) with potential antidepressant properties. It is a derivative of the natural alkaloid harmaline, which is found in the Syrian rue plant. Eseramine works by blocking the reabsorption of serotonin in the brain, thereby increasing its availability and potentially alleviating symptoms of depression. Research on Eseramine is still in the early stages, but it has shown promise in preclinical studies for its ability to modulate serotonin levels and potentially offer a new treatment option for mood disorders.

6091-57-2

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6091-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6091-57-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,9 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6091-57:
(6*6)+(5*0)+(4*9)+(3*1)+(2*5)+(1*7)=92
92 % 10 = 2
So 6091-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H22N4O3/c1-16-7-8-20(14(21)17-2)13(16)19(4)12-6-5-10(9-11(12)16)23-15(22)18-3/h5-6,9,13H,7-8H2,1-4H3,(H,17,21)(H,18,22)/t13-,16-/m0/s1

6091-57-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (-)-eseramine

1.2 Other means of identification

Product number -
Other names (3aS)-3a,8-dimethyl-1-methylcarbamoyl-5-methylcarbamoyloxy-(3ar,8ac)-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6091-57-2 SDS

6091-57-2Downstream Products

6091-57-2Relevant academic research and scientific papers

Synthesis and Anticholinesterase Activity of (-)-N1-Norphysostigmine, (-)-Eseramine, and Other N(1)-Substituted Analogues of (-)-Physostigmine

Yu, Qian-Sheng,Atack, John R.,Rapoport, Stanley I.,Brossi, Arnold

, p. 2297 - 2300 (2007/10/02)

(-)-N1-Benzylnorphysostigmine (4), prepared from synthetic (-)-O-methyl-N1-noreseroline (1) by N-benzylation, ether cleavage, and reaction of (-)-N1-benzylnoreseroline (3) with methyl isocyanate, was the intermediate used to prepare the title compounds.Catalytic debenzylation of (4) afforded (-)-N1-norphysostigmine (5), and (-)-eseramine (6) was obtained by reaction of 5 with methyl isocyanate.Reductive N-methylation of 5 gave (-)-physostigmine (9) while reaction of 5 with allyl bromide and phenethyl bromide afforded carbamates 7 and 8, respectively.Data on the in vitro potencies (IC50) and activities of certain of these compounds (4-8) as inhibitors of electric eel acetyl cholinesterase are reported. (-)-N1-Norphysostigmine (5) was found to be similarly potent against AChE as (-)-physostigmine (9).

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