60925-92-0Relevant academic research and scientific papers
A facile deprotection of secondary acetamides
Koenig, Stefan G.,Vandenbossche, Charles P.,Zhao, Hang,Mousaw, Patrick,Singh, Surendra P.,Bakale, Roger P.
, p. 433 - 436 (2009)
(Chemical Equation Presented) Imidoyl chlorides, generated from secondary acetamides and oxalyl chloride, can be harnessed for a selective and practical deprotection sequence. Treatment of these intermediates with 2 equiv of propylene glycol and warming enables the rapid release of amine hydrochloride salts in good yields. Notably, the reaction conditions are mild enough to allow for a swift deprotection with no observed epimerization of the amino center.
