60927-95-9

Basic information

• Product Name: 1-(4-chlorobenzyl)imidazolidin-2-one
• CAS NO: 60927-95-9
• Molecular Formula: C₁₀H₁₁ClN₂O
• Molecular Weight: 210.6601
• Mol File: 60927-95-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 433.5°C at 760 mmHg
• Flash Point: 216°C
• Density: 1.295g/cm³
• Vapor Pressure: 1.02E-07mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 1-(4-chlorobenzyl)imidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorobenzyl)imidazolidin-2-one(60927-95-9)
• EPA Substance Registry System: 1-(4-chlorobenzyl)imidazolidin-2-one(60927-95-9)

Safety Data

• Hazardous Substances Data: 60927-95-9(Hazardous Substances Data)

Usage

General Description

1-(4-chlorobenzyl)imidazolidin-2-one is a chemical compound that belongs to the imidazolidin-2-one family. It is a white crystalline solid soluble in organic solvents and has a melting point of around 113-115°C. 1-(4-chlorobenzyl)imidazolidin-2-one is often used as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also employed as a key starting material in the production of fungicides, insecticides, and herbicides. Additionally, 1-(4-chlorobenzyl)imidazolidin-2-one exhibits antimicrobial properties and is used in the formulation of personal care products such as lotions, creams, and deodorants. However, it is important to handle this compound with caution as it is a potential irritant to the skin, eyes, and respiratory system.

Upstream product

• 120-93-4 imidazolidone 
• 622-95-7 4-chlorobenzyl bromide 
• 335059-94-4 [2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 1216943-96-2 1-(4-chlorobenzyl)imidazolidine-2-thione 

Relevant articles and documents

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.

Anti-inflammatory 1-(substituted benzyl)-2-imidazolidinones

Certain 1-(substituted benzyl)-2-imidazolidinones of the formula: SPC1 Wherein Ar is 4-chlorophenyl, 3-fluorophenyl, 2,3-dichlorophenyl, and 1-naphthyl possess pharmacological activity as anti-inflammatory agents.