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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(4-chlorobenzyl)imidazolidin-2-one is used as a versatile intermediate for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and chemical products in these sectors.
Used in Pesticide Production:
1-(4-chlorobenzyl)imidazolidin-2-one serves as a key starting material in the production of fungicides, insecticides, and herbicides, playing a crucial role in the creation of these essential agricultural chemicals.
Used in Personal Care Products:
Due to its antimicrobial properties, 1-(4-chlorobenzyl)imidazolidin-2-one is utilized in the formulation of personal care products such as lotions, creams, and deodorants, enhancing their effectiveness in maintaining hygiene and preventing microbial growth.
Caution:
It is important to handle 1-(4-chlorobenzyl)imidazolidin-2-one with care, as it can be a potential irritant to the skin, eyes, and respiratory system, necessitating proper safety measures during its use and production.

Upstream product

• 120-93-4 imidazolidone 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 335059-94-4 [2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 1216943-96-2 1-(4-chlorobenzyl)imidazolidine-2-thione 

Relevant academic research and scientific papers

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.

Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis

The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1

Anti-inflammatory 1-(substituted benzyl)-2-imidazolidinones

Certain 1-(substituted benzyl)-2-imidazolidinones of the formula: SPC1 Wherein Ar is 4-chlorophenyl, 3-fluorophenyl, 2,3-dichlorophenyl, and 1-naphthyl possess pharmacological activity as anti-inflammatory agents.