609346-34-1

Basic information

• Product Name: Propanedioic acid, 2-(acetylamino)-2-(1-methylethyl)-, 1-ethyl ester
• Synonyms: Propanedioic acid, 2-(acetylamino)-2-(1-methylethyl)-, 1-ethyl ester
• CAS NO: 609346-34-1
• Molecular Formula: C10H17NO5
• Molecular Weight: 231.25
• Mol File: 609346-34-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanedioic acid, 2-(acetylamino)-2-(1-methylethyl)-, 1-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, 2-(acetylamino)-2-(1-methylethyl)-, 1-ethyl ester(609346-34-1)
• EPA Substance Registry System: Propanedioic acid, 2-(acetylamino)-2-(1-methylethyl)-, 1-ethyl ester(609346-34-1)

Safety Data

• Hazardous Substances Data: 609346-34-1(Hazardous Substances Data)

Upstream product

• 64724-68-1 diethyl 2-N-acetylamino-2-isopropylmalonate 

Relevant articles and documents

α-amino acid derivatives by enantioselective decarboxylation

The methodology of enantioselective decarboxylation was applied to 2-aminomalonic acid derivatives in order to obtain enantio-enriched amino acid derivatives. Full conversion was achieved stirring racemic N-acetylated 2-aminomalonic hemiesters in THF at 70 °C with 10 mol % of a chiral base for 24 h. The catalyst may be recycled. Whereas the commercially available cinchona alkaloids gave poor results, benzamide and benzenesulfonamide derivatives of 9-amino(9-deoxy)epicinchonine turned out to be effective catalysts. The best result was obtained with 2-N-acetylamino-2-ethoxy-carbonyl-3-phenylpropionic acid as the starting material and N-(9-deoxyepicinchonine-9-yl)-4-methoxybenzamide as the chiral base to give ethyl N-acetyl-L-phenylalaninate in 70% ee. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.