609349-31-7Relevant academic research and scientific papers
NOVEL COMPOUNDS
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Page 15-16, (2008/06/13)
The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to anilin
Anilinopyrazole as selective CDK2 inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic analysis
Tang, Jun,Shewchuk, Lisa M.,Sato, Hideyuki,Hasegawa, Masaichi,Washio, Yoshiaki,Nishigaki, Naohiko
, p. 2985 - 2988 (2007/10/03)
A novel series of anilinopyrazoles has been designed based on the X-ray crystal structure analysis. Most compounds from this series not only show sub-nanomolar IC50 values for CDK2, but also demonstrate almost 1000-fold selectivity to other kinases including CDK1.
