60945-03-1Relevant academic research and scientific papers
An efficient green synthesis of new benzothiazoles containing sulfonamide or cyclic imide moieties
Bougheloum, Chafika,Alioua, Sabrina,Belghiche, Robila,Benali, Nesma,Messalhi, Abdelrani
supporting information, p. 120 - 131 (2019/12/24)
An efficient and convenient protocol for the one-pot synthesis of new benzothiazoles bearing sulfonamide or cyclic imide moieties using Cesium salt of Wells-Dawson heteropolyacid (Cs5HP2W18O62) as solid catalyst and water as solvent under ultrasound irradiation was reported. The reaction speed was remarkably catalyzed with the aid of ultrasound irradiation. Moreover, this approach prepares multiple other benefits such as operational ease, higher yields, and energy performance.
Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents
Casal, Juan José,Bollini, Mariela,Lombardo, María Elisa,Bruno, Ana María
, p. 114 - 119 (2016/01/09)
A series of related thalidomide derivatives (2-9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the highest levels of inhibition of TNF-α production. On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity. Thus, compound 9 can be considered as a promising compound to be subjected to further modification to obtain new agents for the treatment of inflammatory diseases.
Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives
Nagarajan, Shunmugam,Majumder, Syamantak,Sharma, Upendra,Rajendran, Saranya,Kumar, Neeraj,Chatterjee, Suvro,Singh, Bikram
supporting information, p. 287 - 290 (2013/02/23)
Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control. Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control in ex vivo angiogenesis.
