60971-83-7

Basic information

• Product Name: 1H-Purine-2,6-dione, 3,7-dihydro-1-(3-iodopropyl)-3,7-dimethyl-
• CAS NO: 60971-83-7
• Molecular Formula: C10H13IN4O2
• Molecular Weight: 348.143
• Mol File: 60971-83-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Purine-2,6-dione, 3,7-dihydro-1-(3-iodopropyl)-3,7-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purine-2,6-dione, 3,7-dihydro-1-(3-iodopropyl)-3,7-dimethyl-(60971-83-7)
• EPA Substance Registry System: 1H-Purine-2,6-dione, 3,7-dihydro-1-(3-iodopropyl)-3,7-dimethyl-(60971-83-7)

Safety Data

• Hazardous Substances Data: 60971-83-7(Hazardous Substances Data)

Upstream product

• 74409-52-2 1-(3-chloropropyl)-3,7-dimethyl-2,3,6,7-tetrahydro-1H-2,6-purinedione 

Downstream Products

• 81995-83-7 1-benzhydryl-4-[3-(3,7-dimethyl-2,6(3H,7H)-dioxo-1H-purine-1-yl)-propyl]piperazine 

Relevant articles and documents

Synthesis, brain antihypoxic activity and cell neuroprotection of 1-substituted-3,7-dimethylxanthines

Five newly synthesised original compounds were investigated for cute toxicity, influence on hexobarbital sleeping time, effect on the locomotor activity, and brain antihypoxic activity. Two of the compounds were tested in a model of glutamate induced neurotoxicity in the brain cell culture using a cell viability test. Our studies indicate that compounds 2a-c and 4 prolonged the survival time of mice in the model of anoxic hypoxia. Only compound 3 expressed antihypoxic activity in the model of circulatory hypoxia, evaluated with a statistical significant increase of the survival time. Compound 4 (1-[3-(2,3,dihydro-3-oxobenzisosulfonazol-2-yl)-propyl]-3,7-dimethylxanthine) in concentration range 0.3-3 μM statistically significantly antagonised the gutamate induced neurotoxicity. Compound 4 is important for further investigations on in vivo models of brain dementia. (C) 2000 Editions scientifiques et medicales Elsevier SAS.