60972-04-5Relevant academic research and scientific papers
4-chloro pyrrolo[2,3-d]pyrimidine substituted compound and synthetic method thereof
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Paragraph 0040-0041; 0045, (2019/12/02)
The invention relates to a method for synthesizing 4-chloro pyrrolo[2,3-b] pyridine. The method mainly comprises three steps: 1) carrying out p-toluenesulfonyl chloride protection on a 4-chloro pyrrolo[2,3-d]pyrimidine compound; 2) reacting the 4-chloro p
Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors
Tedder, Martina E.,Nie, Zhe,Margosiak, Stephen,Chu, Shaosong,Feher, Victoria A.,Almassy, Robert,Appelt, Krzysztof,Yager, Kraig M.
, p. 3165 - 3168 (2007/10/03)
The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.
