609769-94-0Relevant academic research and scientific papers
Toward the design of novel polynuclear platinum antitumor complexes: A polydentate ligand system based on dipyridylamine and 1,3,5-trimethylenebenzene
Tu, Chao,Lin, Jun,Shao, Ying,Guo, Zijian
, p. 5795 - 5797 (2003)
A novel hexadentate ligand, N,N,N′,N′,N″,N″ -hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene (L), was designed and synthesized. The X-ray structure analysis reveals that the three dipyridylamine (DPA) groups of L are almost perpendicular to the central trimethylenebenzene, and two of them are spacially close to each other while the third one is further apart. The trinuclear Pt(II) complexes [Pt3LCl6] (1) and [Pt3L(CBDCA)3] (2) (where CBDCA represents cyclobutane dicarboxylic acid) were prepared and fully characterized by IR, NMR, and ESMS spectroscopy. A mononuclear complex, [PtL(CBDCA)] (3), was also prepared and structurally characterized, which suggests that controlled formation of mono-, di-, and trinuclear complexes with L is possible. Spectroscopic data showed that complexes 2 and 3 are able to bind to calf thymus DNA and their CBDCA group can be readily replaced by thiourea.
