Basic information

Product Name: 2-Hydroxymethyl Loratadine
Synonyms: Loratadine 2-Hydroxymethyl Impurity (USP);2-Hydroxymethyl Loratadine;4-[8-Chloro-5,6-dihydro-2-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Este;4-[8-Chloro-5,6-dihydro-2-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Ester;Ethyl 4-[8-chloro-5,6-dihydro-2-(hydroxy methyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine carboxylate;Loratadine Impurity 2
CAS NO:609806-39-5
Molecular Formula: C23H25ClN2O3
Molecular Weight: 412.914
EINECS: N/A
Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File: 609806-39-5.mol

Chemical Properties

Melting Point: 76-78°C
Boiling Point: 585.5±50.0 °C(Predicted)
Flash Point: N/A
Appearance: /
Density: 1.301±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: -20°C Freezer
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
PKA: 13.40±0.10(Predicted)
CAS DataBase Reference: 2-Hydroxymethyl Loratadine(CAS DataBase Reference)
NIST Chemistry Reference: 2-Hydroxymethyl Loratadine(609806-39-5)
EPA Substance Registry System: 2-Hydroxymethyl Loratadine(609806-39-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 609806-39-5(Hazardous Substances Data)

Suppliers
Usage
SDS
Upstream product
Downstream Products

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609806-39-5 Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxymethyl Loratadine is used as an impurity in the production of Loratadine syrup formulations for the treatment of allergic symptoms such as sneezing, itching, watery eyes, and runny nose. As a nonsedating antihistamine, Loratadine provides relief without causing drowsiness, making it suitable for daily use.
Used in Quality Control and Regulatory Compliance:
2-Hydroxymethyl Loratadine is used as a reference standard for quality control and regulatory compliance in the pharmaceutical industry. It helps ensure the purity, potency, and safety of Loratadine syrup formulations by providing a benchmark for comparison during testing and analysis.
Used in Research and Development:
2-Hydroxymethyl Loratadine serves as a valuable compound for research and development in the pharmaceutical sector. It can be used to study the effects of impurities on the efficacy and safety of Loratadine syrup, as well as to develop new methods for impurity detection and removal. This contributes to the ongoing improvement of drug formulations and the advancement of pharmaceutical technology.

Check Digit Verification of cas no

The CAS Registry Mumber 609806-39-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,9,8,0 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 609806-39:
(8*6)+(7*0)+(6*9)+(5*8)+(4*0)+(3*6)+(2*3)+(1*9)=175
175 % 10 = 5
So 609806-39-5 is a valid CAS Registry Number.

609806-39-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-Hydroxymethyl Loratadine

1.2 Other means of identification

Product number	-
Other names	ethyl 4-[8-chloro-2-(hydroxymethyl)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-c]pyridin-11-ylidene]piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:609806-39-5 SDS

609806-39-5Upstream product

609806-39-5Downstream Products

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