609810-72-2Relevant academic research and scientific papers
TFA-mediated intramolecular Friedel-Crafts reaction. An efficient metal and halogen free route to stereoselective synthesis of benzocycles
Ma, Shengming,Zhang, Junliang
, p. 6273 - 6283 (2003)
6-Acetoxy-4-alkenyl arenes undergo regio- and stereoselective intramolecular Friedel-Crafts reaction affording benzocycles in moderate to excellent yields in TFA/HOAc (3:1). It was observed that introduction of alkyls or phenyl group to the allylic acetate moiety facilitates the cyclization reaction. The optically active tricyclic (4bR,8aS)-4b,7,8,8a,9,10-hexahydrophenanthrene skeleton could also be easily obtained in excellent yields.
