60984-36-3Relevant academic research and scientific papers
Vasorelaxant activity of phthalazinones and related compounds
Olmo, Esther del,Barboza, Bianca,Ybarra, Ma Ines,Lopez-Perez, Jose Luis,Carron, Rosalia,Sevilla, Ma Angeles,Boselli, Cinthia,Feliciano, Arturo San
, p. 2786 - 2790 (2007/10/03)
Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10-5 M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC50 = 0.43 μM) the affinities for α1A, α1B and α1D adrenergic sub-receptors were determined.
The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds
Del Olmo, Esther,Armas, Marlon Garcia,Ybarra, Ma. Ines,Lopez, Jose Luis,Oporto, Patricia,Gimenez, Alberto,Deharo, Eric,San Feliciano, Arturo
, p. 2769 - 2772 (2007/10/03)
The in vitro antiplasmodial activity of some dihydrostilbenamides, phtalazinones, imidazo[2,1-a]isoindole and pyrimido[2,1-a]isoindole derivatives related to the natural dihydrostilbenoid isonotholaenic acid is reported. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum and potent representative compounds were also evaluated in the ferriprotoporphyrin IX biomineralization inhibition test (FBIT). Compounds having the imidazo[2,1-a]isoindole skeleton were the most active and one compound of this group resulted to be as potent as chloroquine, but acting through a mechanism different that of the inhibition of heme biomineralization.
Leishmanicidal activity of some stilbenoids and related heterocyclic compounds
Del Olmo, Esther,Armas, Marlon Garcia,Lopez-Perez, Jose Luis,Muoz, Victoria,Deharo, Eric,San Feliciano, Arturo
, p. 2123 - 2126 (2007/10/03)
We have evaluated the leishmanicidal activity of some natural and semisynthetic dihydrostilbenoids and several compounds of other series of dihydrostilbamides, isoindoles, phthalazinones, imidazoisoindoles and pyrimidoisoindoles. The evaluation was performed in vitro, on cultures of cutaneous, mucocutaneous and visceral strains of Leishmania spp. The most potent and selective compounds of these series were the dihydrostilbene piperidides.
