610-14-0

Basic information

• Product Name: 2-Nitrobenzoyl chloride
• Synonyms: 2-nitro-benzoylchlorid;Benzoyl chloride, 2-nitro-;Benzoyl chloride, o-nitro-;o-nitro-benzoylchlorid;O-NITROBENZOYL CHLORIDE;2-NITROBENZOYL CHLORIDE;2-Nitrobenzoylchloride,94%;ORTHO-NITROBENZOYLCHLORIDE
• CAS NO: 610-14-0
• Molecular Formula: C₇H₄ClNO₃
• Molecular Weight: 185.56
• EINECS: 210-206-4
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 610-14-0.mol
• Article Data: 111

Chemical Properties

• Melting Point: 17-20 °C(lit.)
• Boiling Point: 148-149 °C9 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to orange to dark brown/Liquid After Melting
• Density: 1.404 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00212mmHg at 25°C
• Refractive Index: n20/D 1.569(lit.)
• Storage Temp.: 0-6°C
• BRN: 777991
• CAS DataBase Reference: 2-Nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitrobenzoyl chloride(610-14-0)
• EPA Substance Registry System: 2-Nitrobenzoyl chloride(610-14-0)

Safety Data

• Hazard Codes: C
• Statements: 5-34
• Safety Statements: 26-36/37/39-45-7/9-38
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: DM6650000
• F: 4.4-9-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 610-14-0(Hazardous Substances Data)

Usage

General Description

Crystalline solid. 2-Nitrobenzoyl chloride is shock sensitive.

Air & Water Reactions

Insoluble in water. Decomposes in water.

Reactivity Profile

2-Nitrobenzoyl chloride is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react with reducing agents. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

ACUTE/CHRONIC HAZARDS: 2-Nitrobenzoyl chloride is an irritant to skin, eyes and tissues.

Fire Hazard

Flash point data is not available for 2-Nitrobenzoyl chloride, but 2-Nitrobenzoyl chloride is probably combustible.

InChI:InChI=1/C7H4ClNO3/c8-7(10)5-3-1-2-4-6(5)9(11)12/h1-4H

Upstream product

• 98-88-4 benzoyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 118-92-3 anthranilic acid 
• 88-72-2 1-methyl-2-nitrobenzene 

Downstream Products

• 69413-21-4 3,5-dimethyl-1-(2-nitro-benzoyl)-1H-pyrazole 
• 574758-55-7 1-(2-nitro-benzoyl)-1H-indazole 
• 22979-83-5 2-nitro-N-(4-methoxyphenyl)benzamide 
• 87866-40-8 2-nitro-benzoic acid diphenylamide 
• 107616-19-3 2-propenyl o-nitrobenzoate 
• 2385-27-5 N-phenyl-2-nitrobenzamide 
• 20887-06-3 N-(2-aminobenzyl)aniline 
• 65347-82-2 6-Nitrobenzoyleneurea 
• 71319-20-5 (4-methylphenyl)(2-nitrophenyl)methanone 
• 102630-95-5 2-nitro-benzoic acid-(2,4-dimethyl-anilide) 
• 61494-29-9 2-nitro-benzoic acid-(N-methyl-o-toluidide) 
• 54108-15-5 2-nitro-N-(4,5,6,7-tetrahydro-benzo[c]isoxazol-3-yl)-benzamide 
• 74415-24-0 2-(2-nitrophenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF

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Divergent Syntheses of Indoles and Quinolines Involving N1-C2-C3 Bond Formation through Two Distinct Pd Catalyses

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AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS

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Method for preparing 2-amino-4'-fluorobenzophenone

The invention discloses a method for preparing 2-amino-4'-fluorobenzophenone. The method comprises the following steps: o-nitrotoluene, trichloroisocyanuric acid, tetramethylpiperidine nitrogen oxideand sodium bromide undergo an oxidation reaction to obtain o-nitrobenzoic acid; the o-nitrobenzoic acid and trichloromethyl carbonate undergo an acylating chlorination to obtain o-nitrobenzoyl chloride; the o-nitrobenzoyl chloride, fluorobenzene and aluminum trichloride undergo a Friedel-Crafts reaction to obtain 2-nitro-4'-fluorobenzophenone; and the 2-nitro-4'-fluorobenzophenone is reduced by hydrogen to the 2-amino-4'-fluorobenzophenone. The method has the advantages of green and environmentally-friendly synthesis route, cheap and easily available initial raw materials, low cost, convenience in operation, suitableness for industrial production, and high yield, and the prepared 2-amino-4'-fluorobenzophenone has a good purity.

Synthesis, characterization and microbial activity of new aryl esters of 1,1'-bis(4-hydroxyphenyl)cyclohexane

Aryl esters of 1,1'-bis(4-hydroxyphenyl)cyclohexane (bisphenol-C) were synthesized by condensing bisphenol-C with aryl acid chlorides using triethylamine as a catalyst and ethyl acetate as a solvent at room temperature.The compounds were characterized by

Synthesis and Quantitative Structure-Activity Relationships of Selective BCRP Inhibitors

The breast cancer resistance protein (BCRP/ABCG2) is a member of the ABC transporter superfamily. This protein has a number of physiological functions, including protection of the human body from xenobiotics. The overexpression of BCRP in certain tumor cell lines causes cross-resistance against various drugs used in chemotherapeutic treatment. In a previous work we showed that a new class of compounds derived from XR9576 (tariquidar) selectively inhibits BCRP. In this work we synthesized more members of this class, with modification on the second and third aromatic rings. The inhibitory activities against BCRP and P-gp were assayed using a Hoechst 33342 assay for BCRP and a calcein AM assay for P-gp. Finally, quantitative structure-activity relationships for both aromatic rings were established. The results obtained show the importance of the electron density on the third aromatic ring, influenced by substituents, pointing to interactions with aromatic residues of the protein binding site. In the second aromatic ring the activity of compounds is influenced by the steric volume of the substituents.

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro

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