610-51-5

Basic information

• Product Name: 4-methylacridine
• Synonyms: 4-methylacridine
• CAS NO: 610-51-5
• Molecular Formula: C₁₄H₁₁N
• Molecular Weight: 193.24384
• EINECS: 210-226-3
• Mol File: 610-51-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 114 °C
• Boiling Point: 361.9 °C at 760 mmHg
• Flash Point: 160 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 4.19E-05mmHg at 25°C
• Refractive Index: 1.703
• PKA: 5.61±0.10(Predicted)
• CAS DataBase Reference: 4-methylacridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylacridine(610-51-5)
• EPA Substance Registry System: 4-methylacridine(610-51-5)

Safety Data

• Hazardous Substances Data: 610-51-5(Hazardous Substances Data)

Usage

General Description

4-Methylacridine, also known as 4-methyldibenzo[b,f]quinoline, is an organic compound consisting of a central acridine ring with a methyl group at the 4-position. It is a yellowish crystalline solid that is sparingly soluble in water but more soluble in organic solvents. 4-Methylacridine is used as a building block in the synthesis of various pharmaceuticals, dyes, and other chemicals. It has also been studied for its potential biological and medicinal properties, including as an antitumor and antibacterial agent. However, it is important to handle 4-methylacridine with caution as it is flammable and may be harmful if ingested, inhaled, or in contact with the skin.

InChI:InChI=1/C14H11N/c1-10-5-4-7-12-9-11-6-2-3-8-13(11)15-14(10)12/h2-9H,1H3

Upstream product

• 82757-38-8 1-(2,6-dimethylphenyl)-1H-benzo[d][1,2,3]triazole 
• 68506-36-5 4-methyl-10H-acridin-9-one 
• 38514-89-5 2,6-dimethyl-N-(2-nitrophenyl)aniline 
• 76943-54-9 4-methyl-9,10-dihydroacridine 
• 271-58-9 anthranil 
• 1374643-16-9 bis(2-methylphenyl)iodonium trifluoromethanesulfonic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 95-53-4 o-toluidine 
• 1512859-11-8 C₂₁H₂₀N₂ 
• 446-52-6 2-Fluorobenzaldehyde 
• 1512859-22-1 C₁₄H₁₂FN 
• 1066-45-1 trimethyltin(IV)chloride 
• 602302-56-7 9-bromo-4-methylacridine 
• 105201-08-9 2-amino-2',6'-dimethyldiphenylamine hydrochloride 

Downstream Products

• 578-95-0 10H-acridin-9-one 
• 113139-12-1 N'-(1-acridinylmethylidene)-4-dimethylaminoaniline N'-oxide 

Relevant articles and documents

Cu-catalyzed cascade reaction of isoxazoles with diaryliodonium salts for the synthesis of acridines

A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has gone through tandem double arylation and Friedel-Crafts reactions.

Preparation method of multi-functional group acridine compound and derivative thereof

The present invention relates to a preparation method of a multi-functional group acridine compound and a derivative thereof. According to the present invention, specifically a bisphosphine ligand and palladium complex catalyzed series connection coupling/cyclization reaction is used to prepare the acridine compound represented by a formula I, wherein various groups are defined in the specification; and the method has advantages of mild reaction condition, simple operation and wide substrate applicability, and the multi-functional group acridine compound and the derivative thereof can be prepared in the high yield manner. The formula I is defined in the specification.

Facile synthesis of acridine derivatives by ZnCl2-promoted intramolecular cyclization of o -arylaminophenyl schiff bases

A concise and efficient method for the synthesis of a wide range of acridine derivatives and polycyclic aza-aromatic compounds from a ZnCl 2-promoted cyclization reaction of readily available o-arylaminophenyl Schiff base compounds under convenient conditions was developed. Reaction conditions and scope of the new method were examined in detail.