61001-53-4Relevant academic research and scientific papers
Antireproductive imidazo[2,1-a]isoquinoline compounds
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, (2008/06/13)
Novel tricyclic compounds containing two ring notrogen atoms and represented by the following formula I STR1 wherein: A is one of the groups --CH2 --; --CH=CH--; and --CH2 --CH2 --; R is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cyclo(C3-6 alkyl)oxy, hydroxy, benzyloxy, halo, sulfamoyl, cyano, trifluoromethyl or nitro; R1 is hydrogen, lower alkoxy or halo; or R and R1 taken together are methylenedioxy; the sequence STR2 is one of the following moieties: STR3 WHEREIN R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; R4 is hydrogen, methyl, carboxy, carbo(lower alkoxy), carbamyl, mono- or di-(lower alkyl) carbamyl or hydroxymethyl; provided that when the sequence STR4 is one of the moieties a) and b) wherein R2 is hydrogen or lower alkyl, A is not --CH=CH--; when the sequence STR5 is one of the moieties (a) and (b) wherein R2 is hydrogen, A is not --CH2 --; and when the sequence STR6 is one of the moieties (c) and (d) wherein R3 is hydrogen and when both R and R1 are hydrogen, A is not --CH=CH--; and the salts thereof with a non-toxic pharmaceutically-acceptable acid. The compounds of the invention have antireproductive activity.
