6101-31-1

Basic information

• Product Name: 4-AMINOBENZENESULPHONAMIDE HCL
• Synonyms: 4-AMINOBENZENESULPHONAMIDE HCL;4-Aminobenzenesulfonamide hydrochloride
• CAS NO: 6101-31-1
• Molecular Formula: C₆H₈N₂O₂S*ClH
• Molecular Weight: 0
• Mol File: 6101-31-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 311 °C (decomp)
• Boiling Point: 400.5°C at 760 mmHg
• Flash Point: 196°C
• Appearance: /
• Vapor Pressure: 1.27E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-AMINOBENZENESULPHONAMIDE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOBENZENESULPHONAMIDE HCL(6101-31-1)
• EPA Substance Registry System: 4-AMINOBENZENESULPHONAMIDE HCL(6101-31-1)

Safety Data

• Hazardous Substances Data: 6101-31-1(Hazardous Substances Data)

Usage

General Description

4-aminobenzenesulfonamide hydrochloride (4-ABS) is a chemical compound that belongs to the sulfonamide class of antibiotics. It is commonly used as a bacteriostatic agent to inhibit the growth of various bacteria by interfering with their synthesis of folic acid. 4-ABS works by competing with para-aminobenzoic acid for the enzyme dihydropteroate synthase, which disrupts the production of dihydrofolic acid and subsequently inhibits the biosynthesis of purines and pyrimidines. This can ultimately lead to the inhibition of bacterial growth and proliferation. In addition to its antibacterial properties, 4-ABS has also been investigated for its potential use in the treatment of certain types of cancer and systemic lupus erythematosus.

InChI:InChI=1/C6H8N2O2S.ClH/c7-5-1-3-6(4-2-5)11(8,9)10;/h1-4H,7H2,(H2,8,9,10);1H

Upstream product

• 121-61-9 p-acetylaminobenzenesulfonamide 
• 63-74-1 sulfanilamide 
• 14949-01-0 2-chloro-N-(4-sulfamoylphenyl)acetamide 

Downstream Products

• 122027-32-1 N-(4,6-dimethyl-pyrimidin-2-yl)-N'-(4-sulfamoyl-phenyl)-guanidine 
• 222035-01-0 4-[(5-Oxazol-5-yl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]benzenesulfonamide 
• 51908-29-3 4-isothiocyanatobenzene sulfonamide 
• 58590-29-7 2-phenoxy-N-(4-sulfamoylphenyl)acetamide 
• 497087-21-5 N-[(2-chloro-phenoxy)-acetyl]-sulfanilic acid amide 
• 5626-85-7 4-guanidinobenzenesulfonamide 

Relevant articles and documents

A facile and efficient method for the selective deacylation of N-arylacetamides and 2-chloro-Narylacetamides catalyzed by SOCl2

Thionyl chloride efficiently and selectively promoted the deacylation of N-arylacetamides and 2-chloro-N-arylacetamides, under anhydrous conditions, without effecting the ester group, aminosulfonyl group, or benzyloxyamide group. This method, which has been successfully applied to a variety of substrates including different N-arylacetamides and 2-chloro-N-arylacetamides, has the attractive advantages of inexpensive reagents, satisfactory selectivity, excellent yields, short reaction time, and convenient workup. This new method can probably be used to selectively deacylate between aromatic amides and alkyl amides. Springer Science+Business Media B.V. 2011.