61018-63-1Relevant academic research and scientific papers
Novel pyrimidine and 1,3,5-triazine hypolipidemic agents
d'Atri,Gomarasca,Resnati,Tronconi,Scolastico,Sirtori
, p. 1621 - 1629 (2007/10/02)
New compounds were synthesized by changing the substituents of a trisubstituted pyrimidine, i.e., [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid, a potent hypolipidemic agent, impaired, however, by a marked hepatomegaly-inducing effect. The structural variations led to the subsidence (14b, i.e., 4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine) or to the reduction (18b, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]amino]acetic acid) of said untoward effect but still maintained the hypolipidemic effect that, although markedly decreased, still proves significant for serum cholesterol and triglycerides (18b) or for serum triglycerides only (14b).
4-Pyrimidinylthioacetic acid derivatives
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, (2008/06/13)
The compounds SPC1 In which the symbol A represents a carbon or nitrogen atom, X represents --Cl, lower alkoxy or the substituted amino group SPC2 Y represents --Cl, lower alkoxy, SPC3 With the proviso that when Y is --Cl, X and Z are other than --Cl, and Z represents --H, --Cl, --OCH2 CO2 R, --SCH2 C CH, SPC4 wherein R and R2 are --H or lower alkyl, R3 is --H, --Cl or lower alkyl, and n represents one of the integers 0 and 1, exhibit anti-lipemic activity and/or central nervous system depressant activity in warm-blooded animals.
