610272-53-2

Upstream product

• 610272-48-5 1-[((E)-3-bromoallyloxy)methyl]benzene 
• 610272-47-4 (E)-(((4,4,4-trifluorobut-2-en-1-yl)oxy)methyl)benzene 
• 610272-49-6 (2S,3R)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol 
• 610272-50-9 (3S,4R)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane 

Downstream Products

• 610272-55-4 thiocarbonic acid O-(3-benzyloxy-2-tert-butoxycarbonylamino-1-trifluoromethyl-propyl) ester O-phenyl ester 
• 610272-56-5 (2S)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutane 
• 181128-25-6 (2S)-2-({[(1,1-dimethylethyl)oxyl]carbonyl}amino)-4,4,4-trifluorobutanoic acid 

Relevant academic research and scientific papers

Asymmetric synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid

A short and efficient enantio selective synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid was successfully developed. Trifluoromethylation of benzyl-protected bromoalkene 4 provided key intermediate trifluoromethylated transdi-substituted alkene 2 in good yield. The sequence then involved Sharpless asymmetric dihydroxylation, nucleophilic opening of cyclic sulfate with NaN3, palladium-catalyzed selective hydrogenation, and oxidation.