610300-75-9

Upstream product

• 108450-08-4 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-yl trifluoromethanesulfonate 
• 610300-88-4 2-[(1S,2S,3R,4S)-3-(dicyclohexylphosphoryl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]pyridine 
• 253783-05-0 (1R,4R)-2-(pyridin-2-yl)-1,7,7-trimethylbicyclo[2.2.1]-2-heptene 

Relevant academic research and scientific papers

CHIRAL LIGANDS AND THEIR TRANSITION METAL COMPLEXES

The invention relates to chiral phosphorus compounds and their transition metal complexes, in addition to the use of said transition metal complexes, in particular in asymmetric syntheses.

New P, N ligands for asymmetric Ir-catalyzed reactions

Chiral Ir complexes such as 1 catalyze the hydrogenation of (E)-1, 2-diphenylpropene at 1 bar of H2 to give (5)-1, 2-diphenylpropane with up to 95% ee and full conversion (see scheme). Methyl (Z)-α -(acetamido)cinnamate underwent enantioselective hydrogenation under similar conditions to the corresponding amino acid derivative with up to 96% ee. BARF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate, cod = 1, 5-cyclooctadiene.