610300-82-8

Upstream product

• 4559-70-0 Diphenylphosphine oxide 
• 253783-05-0 (1R,4R)-2-(pyridin-2-yl)-1,7,7-trimethylbicyclo[2.2.1]-2-heptene 
• 108450-08-4 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-yl trifluoromethanesulfonate 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 

Downstream Products

• 610300-73-7 2-[(1S,2S,3R,4S)-3-(diphenylphosphino)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]pyridine 

Relevant academic research and scientific papers

Chiral ligands and their transition metal complexes

The present invention relates to chiral phosphorus compounds and their transition metal complexes, and also to the use of these transition metal complexes, especially in asymmetric syntheses.

t-BuOK-mediated hydrophosphination of functionalized alkenes: A novel synthesis of chiral P,N- and P,P-ligands

A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-α-(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.

CHIRAL LIGANDS AND THEIR TRANSITION METAL COMPLEXES

The invention relates to chiral phosphorus compounds and their transition metal complexes, in addition to the use of said transition metal complexes, in particular in asymmetric syntheses.

New Applications of Camphor-Derived P,N-Ligands for Asymmetric Pd- and Ir-Catalyzed Reactions

Ir-catalyzed asymmetric hydroboration of bicyclic hydrazine 4 in the presence of chiral ligand 1a, leads to bicyclic alcohol 5 after oxidative workup in good yield (76%) and moderate enantioselectivity (71% ee).