610309-89-2

Usage

Uses

Used in Cardiovascular Medicine:
Carvedilol Phosphate is used as a therapeutic agent for the treatment of congestive heart failure, left ventricular dysfunction following a myocardial infarction, and management of hypertension. Its dual action as a beta-blocker and vasodilator helps to improve heart function, reduce the symptoms of heart failure, and lower blood pressure, providing significant benefits for patients with these conditions.

InChI:InChI=1/2C24H26N2O4.2H3O4P.H2O/c2*1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20;2*1-5(2,3)4;/h2*2-12,17,25-27H,13-16H2,1H3;2*(H3,1,2,3,4);1H2

Upstream product

• 374779-45-0 1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate 
• 72956-09-3 carvedilol 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF CARVEDILOL DIHYDROGEN PHOSPHATE HEMIHYDRATE AND PHARMACEUTICAL COMPOSITIONS THEREOF

There is provided processes for preparing carvedilol dihydrogen phosphate hemihydrate, which processes include at least one of the steps of: (a) providing a solution of carvedilol in a mixture of organic solvent (s) and/or water; (b) adding a phosphonatin

Efficient Process For Production Of Carvedilol Phosphate

A novel cost effective process for the synthesis of phosphate salts of 1-(9H-carbazol-4yloxy)-3-[[2-(2-methoxyphenoxy)ethyl] amino]-propan-2-ol, (carvedilol phosphate) of formula (II) with high yields and purity is disclosed. More particularly, the invention discloses a process for preparation of crystalline phosphate salts of carvedilol using various phosphate forming reagents such as phosphorous pentoxide, polyphosphoric acid, dipotassium hydrogen phosphate, ammonium dihydrogen ortho phosphate, and sodium dihydrogen ortho phosphate in solvents selected from Acetonitrile, acetone and tetrahydrofuran. The solvents used to prepare solvates of carvedilol dihydrogen phosphate are methanol, ethanol and isopropyl alcohol.

NOVEL POLYMORPHIC FORMS OF CARVEDILOL DIHYDROGEN PHOSPHATE AND PROCESS FOR PREPARING THE SAME

The present invention provides novel crystalline polymorphic forms and amorphous form of carvedilol dihydrogen phosphate characterized by different solid state techniques. The novel processes for their preparation are also disclosed.

CARVEDILOL PHOSPHATE SESQUIHYDRATE

The present invention relates a novel crystalline l-(Carbazol-4-yloxy-3-[[2-(o- methoxyphenoxy) ethyl] amino] -2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric a

CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF DELIVERY AND/OR TREATMENT

The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain

CARVEDILOL FREE BASE, SALTS, ANHYDROUS FORMS OR SOLVATE THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULATIONS, AND TREATMENT OR DELIVERY METHODS

The present invention also relates to carvedilol free base, carvedilol salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and delivery or dosing methods of carvedilol forms to the low